A head-to-head comparison of conjugation methods for VHHs: Random maleimide-thiol coupling versus controlled click chemistry

Targeted delivery of therapeutics is an attractive strategy for vascular diseases. Recently, variable domains of heavy-chain-only antibodies (VHHs) have gained momentum as targeting ligands to achieve this. Targeting ligands need adequate conjugation to the preferred delivery platform. When choosing...

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Detalles Bibliográficos
Autores principales: van Moorsel, Marc V.A., Urbanus, Rolf T., Verhoef, S., Koekman, C.A., Vink, Maurice, Vermonden, T., Maas, Coen, Pasterkamp, Gerard, Schiffelers, Raymond M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733300/
https://www.ncbi.nlm.nih.gov/pubmed/31517285
http://dx.doi.org/10.1016/j.ijpx.2019.100020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733300/
https://www.ncbi.nlm.nih.gov/pubmed/31517285
http://dx.doi.org/10.1016/j.ijpx.2019.100020

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