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Industrial application of heat- and mass balance model for fluid-bed granulation for technology transfer and design space exploration
This work demonstrates the application of state-of-the-art modeling techniques in pharmaceutical manufacturing for fluid bed granulation at varying scales to successfully predict process conditions and ultimately replace experiments during a technology transfer of five products. We describe a mathem...
Autores principales: | Ochsenbein, David R., Billups, Matthew, Hong, Bingbing, Schäfer, Elisabeth, Marchut, Alexander J., Lyngberg, Olav K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733368/ https://www.ncbi.nlm.nih.gov/pubmed/31517293 http://dx.doi.org/10.1016/j.ijpx.2019.100028 |
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