In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

The objective of this study was to evaluate in vitro and in vivo drug release from in situ forming gels prepared with poloxamer 338 (P338) and/or 407 (P407) in N-methyl-2-pyrrolidone (NMP)/water mixtures for the model compound bedaquiline fumarate salt. The impact of total poloxamer concentration (2...

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Detalles Bibliográficos
Autores principales: Hemelryck, Sandy Van, Dewulf, Jonatan, Niekus, Harm, van Heerden, Marjolein, Ingelse, Benno, Holm, René, Mannaert, Erik, Langguth, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733418/
https://www.ncbi.nlm.nih.gov/pubmed/31517281
http://dx.doi.org/10.1016/j.ijpx.2019.100016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733418/
https://www.ncbi.nlm.nih.gov/pubmed/31517281
http://dx.doi.org/10.1016/j.ijpx.2019.100016

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