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Size and structure of the sequence space of repeat proteins
The coding space of protein sequences is shaped by evolutionary constraints set by requirements of function and stability. We show that the coding space of a given protein family—the total number of sequences in that family—can be estimated using models of maximum entropy trained on multiple sequenc...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733475/ https://www.ncbi.nlm.nih.gov/pubmed/31415557 http://dx.doi.org/10.1371/journal.pcbi.1007282 |