Administration of Menadione, Vitamin K3, Ameliorates Off-Target Effects on Corneal Epithelial Wound Healing Due to Receptor Tyrosine Kinase Inhibition

PURPOSE: The antiangiogenic receptor tyrosine kinase inhibitor (RTKi), 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl) butyl] amino] carbonyl]amino]-4-isothiazolecarboxamide hydrochloride, targets VEGFR2 (half maximal inhibitory concentration [IC(50)] = 11 nM); however, off-target i...

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Detalles Bibliográficos
Autores principales: Rush, Jamie S., Bingaman, David P., Chaney, Paul G., Wax, Martin B., Ceresa, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733502/
https://www.ncbi.nlm.nih.gov/pubmed/27802516
http://dx.doi.org/10.1167/iovs.16-19952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733502/
https://www.ncbi.nlm.nih.gov/pubmed/27802516
http://dx.doi.org/10.1167/iovs.16-19952

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