3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis

PURPOSE: Transcriptional analysis of retina protected by hypoxia-inducible factor (HIF) stabilization demonstrates an increase in genes associated with aerobic glycolysis. We hypothesized that since protection is associated with a change in metabolism, oxygen-induced metabolites might transduce oxyg...

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Detalles Bibliográficos
Autores principales: Singh, Charandeep, Sharma, Amit, Hoppe, George, Song, Weilin, Bolok, Youstina, Sears, Jonathan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733534/
https://www.ncbi.nlm.nih.gov/pubmed/30025089
http://dx.doi.org/10.1167/iovs.18-24120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733534/
https://www.ncbi.nlm.nih.gov/pubmed/30025089
http://dx.doi.org/10.1167/iovs.18-24120

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