Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study

Metabotropic glutamate receptors (mGluRs) have been proposed as promising therapeutic targets to correct the dysregulated glutamate signaling, associated with neurodegenerative pathologies. Of all mGluR subtypes, especially mGluR5 acts as a modulator of glutamate-induced excitotoxicity. To study the...

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Detalles Bibliográficos
Autores principales: Crabbé, Melissa, Dirkx, Nina, Casteels, Cindy, Laere, Koen Van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733799/
https://www.ncbi.nlm.nih.gov/pubmed/31501497
http://dx.doi.org/10.1038/s41598-019-49356-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733799/
https://www.ncbi.nlm.nih.gov/pubmed/31501497
http://dx.doi.org/10.1038/s41598-019-49356-x

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