Cargando…

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation

Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity—a phenomenon known as paradoxical excitation. Previous studies have identified GABA(A) receptors as the primary targets of most anesthetic drugs, but how these compounds produce parado...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCarroll, Matthew N., Gendelev, Leo, Kinser, Reid, Taylor, Jack, Bruni, Giancarlo, Myers-Turnbull, Douglas, Helsell, Cole, Carbajal, Amanda, Rinaldi, Capria, Kang, Hye Jin, Gong, Jung Ho, Sello, Jason K., Tomita, Susumu, Peterson, Randall T., Keiser, Michael J., Kokel, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733874/ https://www.ncbi.nlm.nih.gov/pubmed/31501447 http://dx.doi.org/10.1038/s41467-019-11936-w

Ejemplares similares

Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds
por: Bruni, Giancarlo, et al.
Publicado: (2016)

Sedatives: Serotonin syndrome and myoclonus: 2 case reports
Publicado: (2021)

Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish
por: Bruni, Giancarlo, et al.
Publicado: (2014)

Assembly rules for GABA(A) receptor complexes in the brain
por: Martenson, James S, et al.
Publicado: (2017)

A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
por: Saxena, Neeraj, et al.
Publicado: (2021)

Serotonin/GABA receptors modulate odor input to olfactory receptor neuron in locusts
por: Lv, Mingyue, et al.
Publicado: (2023)

Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival
por: Pai, Vaibhav P, et al.
Publicado: (2009)

Acid Stimulation (Sour Taste) Elicits GABA and Serotonin Release from Mouse Taste Cells
por: Huang, Yijen A., et al.
Publicado: (2011)

Effects of GABA/β-glucan supplements on melatonin and serotonin content extracted from natural resources
por: Dutta, Sayan Deb, et al.
Publicado: (2021)

Reciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit
por: Xia, Guobin, et al.
Publicado: (2021)

Paradoxical Reactions to Midazolam in a Term Parturient After Intravenous Sedation During Cesarean Section
por: Sivakumar, Sengottaian, et al.
Publicado: (2021)

Propofol Alone versus Propofol in Combination with Midazolam for Sedative Endoscopy in Patients with Paradoxical Reactions to Midazolam
por: Nam, Ji Hyung, et al.
Publicado: (2022)

Bilirubin potentiates etomidate-induced sedation by enhancing GABA-induced currents after bile duct ligation
por: Gao, Hao, et al.
Publicado: (2023)

GABA–glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep
por: Billwiller, Francesca, et al.
Publicado: (2020)

Noradrenaline, Serotonin, GABA, and Glycine in Cerebrospinal Fluid during Labor Pain: A Cross-Sectional Prospective Study
por: Chalermkitpanit, Pornpan, et al.
Publicado: (2017)

Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice
por: Bui, Bich Phuong, et al.
Publicado: (2022)

Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors
por: Linden, Anni-Maija, et al.
Publicado: (2011)

Corelease and Differential Exit via the Fusion Pore of GABA, Serotonin, and ATP from LDCV in Rat Pancreatic β Cells
por: Braun, Matthias, et al.
Publicado: (2007)

The Obesity Paradox and Cardiorespiratory Fitness
por: McAuley, Paul A., et al.
Publicado: (2012)

GABA and the GABA(A) Receptor
por: Mihic, S. John, et al.
Publicado: (1997)

Electrophysiological Assessment of Serotonin and GABA Neuron Function in the Dorsal Raphe during the Third Trimester Equivalent Developmental Period in Mice123
por: Morton, Russell A., et al.
Publicado: (2016)

Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release
por: Dankoski, Elyse C., et al.
Publicado: (2016)

Effect of Thai traditional antinausea remedy on hypnotic and sedative activity in animal experimental models: Interaction with drugs acting at GABA(A) receptor
por: Damjuti, Watchara, et al.
Publicado: (2019)

An In-Vivo Study on Anticonvulsant, Anxiolytic, and Sedative-Hypnotic Effects of the Polyphenol-Rich Thymus Kotschyanus Extract; Evidence for the Involvement of GABA(A) Receptors
por: Jahani, Reza, et al.
Publicado: (2019)

The CERN version of MIST
por: McCarroll, S J
Publicado: (1963)

Simple statistical tests for geography
por: McCarroll, Danny
Publicado: (2016)

Grand Sequences
por: McCarroll, James
Publicado: (1876)

God Help Her
por: McCarroll, James
Publicado: (1892)

Dyslipidemia paradox: Analysis from the veterans exercise testing study
por: Vainshelboim, Baruch, et al.
Publicado: (2023)

Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen
por: Laggner, Christian, et al.
Publicado: (2011)

Moderate sedation: Introducing the “modified sedation continuum” and the “moderate sedation ladder”
por: Eldawlatly, Abdelazeem A.
Publicado: (2014)

Spatial Distributions of GABA Receptors and Local Inhibition of Ca(2+) Transients Studied with GABA Uncaging in the Dendrites of CA1 Pyramidal Neurons
por: Kanemoto, Yuya, et al.
Publicado: (2011)

Vortioxetine Treatment Reverses Subchronic PCP Treatment-Induced Cognitive Impairments: A Potential Role for Serotonin Receptor-Mediated Regulation of GABA Neurotransmission
por: Pehrson, Alan L., et al.
Publicado: (2018)

Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT(3) serotonin and GABA(A) receptors
por: Spirova, Ekaterina N., et al.
Publicado: (2019)

Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP(2) Suggest a Mechanism for Regulation
por: Sisco, Nicholas J., et al.
Publicado: (2019)

Sedation and analgesia practices at Italian neonatal intensive care units: results from the EUROPAIN study
por: Lago, Paola, et al.
Publicado: (2017)

New GABA amides activating GABA(A)-receptors
por: Raster, Peter, et al.
Publicado: (2013)

Health costs of a reduced energy supply.
por: McCarroll, J R
Publicado: (1983)

Remembering the Personal Past: Beyond the Boundaries of Imagination
por: McCarroll, Christopher Jude
Publicado: (2020)

Organic Synthesis Using Environmentally Benign Acid Catalysis
por: Kokel, Anne, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8277gicjpmmkhbh7bau68r60uh