Molecular Basis of BioJ, a Unique Gatekeeper in Bacterial Biotin Synthesis

Biotin is an indispensable cofactor in the three domains of life. The unusual virulence factor BioJ of Francisella catalyzes the formation of pimeloyl-ACP, an intermediate in biotin synthesis. Here, we report the 1.58 Å crystal structure of BioJ, the enzymatic activity of which is determined with th...

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Detalles Bibliográficos
Autores principales: Wei, Wenhui, Guan, Hongxin, Zhu, Tong, Zhang, Sitao, Fan, Chengpeng, Ouyang, Songying, Feng, Youjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733898/
https://www.ncbi.nlm.nih.gov/pubmed/31494495
http://dx.doi.org/10.1016/j.isci.2019.08.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733898/
https://www.ncbi.nlm.nih.gov/pubmed/31494495
http://dx.doi.org/10.1016/j.isci.2019.08.028

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