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Molecular Basis of BioJ, a Unique Gatekeeper in Bacterial Biotin Synthesis
Biotin is an indispensable cofactor in the three domains of life. The unusual virulence factor BioJ of Francisella catalyzes the formation of pimeloyl-ACP, an intermediate in biotin synthesis. Here, we report the 1.58 Å crystal structure of BioJ, the enzymatic activity of which is determined with th...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733898/ https://www.ncbi.nlm.nih.gov/pubmed/31494495 http://dx.doi.org/10.1016/j.isci.2019.08.028 |