Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin

Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses: the primary candidates are synaptotagmin (syt) 1 and complexin I/II. Syt1 is a Ca(2+) sensor f...

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Detalles Bibliográficos
Autores principales: Courtney, Nicholas A., Bao, Huan, Briguglio, Joseph S., Chapman, Edwin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733930/
https://www.ncbi.nlm.nih.gov/pubmed/31501440
http://dx.doi.org/10.1038/s41467-019-12015-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733930/
https://www.ncbi.nlm.nih.gov/pubmed/31501440
http://dx.doi.org/10.1038/s41467-019-12015-w

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