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Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses: the primary candidates are synaptotagmin (syt) 1 and complexin I/II. Syt1 is a Ca(2+) sensor f...
Autores principales: | Courtney, Nicholas A., Bao, Huan, Briguglio, Joseph S., Chapman, Edwin R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733930/ https://www.ncbi.nlm.nih.gov/pubmed/31501440 http://dx.doi.org/10.1038/s41467-019-12015-w |
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