Cargando…

α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

α-Hispanolol (α-H) is a labdane diterpenoid that has been shown to induce apoptosis in several human cancer cells. However, the effect of α-H in human glioblastoma cells has not been described. In the present work, we have investigated the effects of α-H on apoptosis, migration, and invasion of huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sánchez-Martín, Vanesa, Jiménez-García, Lidia, Herranz, Sandra, Luque, Alfonso, Acebo, Paloma, Amesty, Ángel, Estévez-Braun, Ana, de las Heras, Beatriz, Hortelano, Sonsoles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733979/ https://www.ncbi.nlm.nih.gov/pubmed/31551765 http://dx.doi.org/10.3389/fphar.2019.00935

Ejemplares similares

Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking
por: González-Cofrade, Laura, et al.
Publicado: (2022)

Semisynthesis and Inhibitory Effects of Solidagenone Derivatives on TLR-Mediated Inflammatory Responses
por: Cuadrado, Irene, et al.
Publicado: (2018)

Visualization of Lipid Droplets in the Alveolar Macrophage Cell Line MH-S with Live-cell Imaging by 3D Holotomographic Microscopy (Nanolive)
por: Pérez-Montero, Andrea, et al.
Publicado: (2023)

Tumor suppressor ARF regulates tissue microenvironment and tumor growth through modulation of macrophage polarization
por: Jiménez-García, Lidia, et al.
Publicado: (2016)

Synthesis of Quinoline and Dihydroquinoline Embelin Derivatives as Cardioprotective Agents
por: Martín-Acosta, Pedro, et al.
Publicado: (2023)

Role of the tumor suppressor ARF in macrophage polarization: Enhancement of the M2 phenotype in ARF-deficient mice
por: Herranz, Sandra, et al.
Publicado: (2012)

Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP-2 and MMP-9 expression via the p38MAPK signaling pathway
por: Lu, Shuming, et al.
Publicado: (2021)

Tumor suppressor ARF: The new player of innate immunity
por: Través, Paqui G., et al.
Publicado: (2012)

Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game
por: Través, Paqui G., et al.
Publicado: (2012)

Role of P38 MAPK on MMP Activity in Photothrombotic Stroke Mice as Measured using an Ultrafast MMP Activatable Probe
por: Chang, Di, et al.
Publicado: (2015)

Platelet-derived microparticles stimulate the invasiveness of colorectal cancer cells via the p38MAPK-MMP-2/MMP-9 axis
por: Kassassir, Hassan, et al.
Publicado: (2023)

Haemozoin enhances MMP-9 production through MAPK p38-dependent mechanisms in human adherent monocytes
por: Khadjavi, Amina, et al.
Publicado: (2014)

MiR-33 promotes myocardial fibrosis by inhibiting MMP16 and stimulating p38 MAPK signaling
por: Chen, Zhen, et al.
Publicado: (2018)

Bakuchiol Suppresses Inflammatory Responses Via the Downregulation of the p38 MAPK/ERK Signaling Pathway
por: Lim, Hye-Sun, et al.
Publicado: (2019)

Downregulation of Cypher induces apoptosis in cardiomyocytes via Akt/p38 MAPK signaling pathway
por: Xuan, Tianming, et al.
Publicado: (2020)

A Small Non-Coding RNA Modulates Expression of Pilus-1 Type in Streptococcus pneumoniae
por: Acebo, Paloma, et al.
Publicado: (2021)

p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts
por: Sinfield, John K., et al.
Publicado: (2013)

IFITM3 promotes hepatocellular carcinoma invasion and metastasis by regulating MMP9 through p38/MAPK signaling
por: Min, Jiaqi, et al.
Publicado: (2018)

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB
por: Huang, Xia, et al.
Publicado: (2017)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells
por: Manzano, Sara, et al.
Publicado: (2021)

Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes
por: Schram, Kristin, et al.
Publicado: (2010)

RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway
por: Xu, Yang, et al.
Publicado: (2020)

Small regulatory RNAs in Streptococcus pneumoniae: discovery and biological functions
por: Wilton, Joana, et al.
Publicado: (2015)

Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression
por: Chen, Xueran, et al.
Publicado: (2020)

PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38(MAPK) signalling
por: Lane, Rosemary, et al.
Publicado: (2022)

TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway
por: Cai, Jiayang, et al.
Publicado: (2022)

Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-κB and p38 MAPK in Rheumatoid Synovial Fibroblasts
por: Hanabayashi, Masahiro, et al.
Publicado: (2016)

Metastasis-associated protein 2 regulates human hepatocellular carcinoma metastasis progression through modulating p38MAPK/MMP2 pathways
por: Hsu, Wen-Hung, et al.
Publicado: (2019)

Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling
por: Han, Y, et al.
Publicado: (2016)

LOX inhibition downregulates MMP-2 and MMP-9 in gastric cancer tissues and cells
por: Zhao, Lei, et al.
Publicado: (2019)

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
por: Escós, Alejandra, et al.
Publicado: (2016)

Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways
por: Wu, Li-Chen, et al.
Publicado: (2011)

Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways
por: Wu, Kun-Chang, et al.
Publicado: (2022)

Downregulation of cathepsin C alleviates endothelial cell dysfunction by suppressing p38 MAPK/NF-κB pathway in preeclampsia
por: Lu, Fan, et al.
Publicado: (2022)

p38 MAPK Signaling in Osteoblast Differentiation
por: Rodríguez-Carballo, Eddie, et al.
Publicado: (2016)

p38 MAPK in cardioprotection – are we there yet?
por: Martin, E D, et al.
Publicado: (2015)

P38 MAPK and Radiotherapy: Foes or Friends?
por: García-Flores, Natalia, et al.
Publicado: (2023)

New Insights into the p38γ and p38δ MAPK Pathways
por: Risco, Ana, et al.
Publicado: (2012)

Paris saponin VII suppresses osteosarcoma cell migration and invasion by inhibiting MMP-2/9 production via the p38 MAPK signaling pathway
por: Cheng, Gong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gfptj70ce39u9hlaau0milab1u