Cargando…

Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity

In this study, we report our contribution to the application of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the synthesis of β-keto-1,2,3-triazole derivatives 3a-f from ethinylestradiol and their application in the inhibition of two human cancer cells lines: human breast ade...

Descripción completa

Detalles Bibliográficos
Autores principales:	Queiroz, Thayane M., Orozco, Erika V.M., Silva, Valdenizia R., Santos, Luciano S., Soares, Milena B.P., Bezerra, Daniel P., Porto, André L.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734327/ https://www.ncbi.nlm.nih.gov/pubmed/31517128 http://dx.doi.org/10.1016/j.heliyon.2019.e02408

Ejemplares similares

1,2,3-Triazoles
por: Rachwal, S., et al.
Publicado: (2008)

Semi-Synthesis of New 1,2,3-Triazole Derivatives of 9-Bromonoscapine and their Anticancer Activities
por: Hasanpour, Zahra, et al.
Publicado: (2021)

Versatile Synthetic Platform for 1,2,3-Triazole Chemistry
por: Vala, Disha P., et al.
Publicado: (2022)

Semi-rational engineering an aldo–keto reductase for stereocomplementary reduction of α-keto amide compounds
por: Bai, Ruixuan, et al.
Publicado: (2023)

A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells
por: Silva, Valdenizia Rodrigues, et al.
Publicado: (2018)

Synthesis of Novel Glycerol-Derived 1,2,3-Triazoles and Evaluation of Their Fungicide, Phytotoxic and Cytotoxic Activities
por: Costa, Adilson Vidal, et al.
Publicado: (2017)

1,2,3-Triazoles as Biomimetics in Peptide Science
por: Agouram, Naima, et al.
Publicado: (2021)

Quercetin-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer’s Agents
por: Carreiro, Elisabete P., et al.
Publicado: (2023)

Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines
por: Hoffman, Gavin R., et al.
Publicado: (2022)

Energetic Polymer Possessing Furazan, 1,2,3-Triazole, and Nitramine Subunits
por: Gribov, Pavel S., et al.
Publicado: (2023)

1,2,3-Triazoles: Controlled Switches in Logic Gate Applications
por: Ghosh, Debanjana, et al.
Publicado: (2023)

Ethinylestradiol/Chlormadinone Acetate: Dermatological Benefits
por: Guerra-Tapia, Aurora, et al.
Publicado: (2012)

Antimicrobial studies of unsymmetrical bis-1,2,3-triazoles
por: Banday, Abid H, et al.
Publicado: (2012)

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
por: Oueis, Emilia, et al.
Publicado: (2016)

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
por: Oueis, Emilia, et al.
Publicado: (2016)

A practical flow synthesis of 1,2,3-triazoles
por: Drelinkiewicz, Dawid, et al.
Publicado: (2022)

1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs
por: Bosch-Sanz, Oriol, et al.
Publicado: (2022)

1,2,3-Triazoles and their metal chelates with antimicrobial activity
por: Todorov, Lozan, et al.
Publicado: (2023)

Synthesis of 1,2,3-Triazole Derivatives and in Vitro Antifungal Evaluation on Candida Strains
por: Lima-Neto, Reginaldo G., et al.
Publicado: (2012)

Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents
por: Nalla, Viswanadh, et al.
Publicado: (2018)

Aurone-derived 1,2,3-triazoles as potential fluorescence molecules in vitro
por: Bryant, Daniel L., et al.
Publicado: (2022)

Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
por: Mortazavi, Motahareh, et al.
Publicado: (2023)

Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives
por: Assis, Shalom Pôrto de Oliveira, et al.
Publicado: (2012)

Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity
por: Pokhodylo, Nazariy, et al.
Publicado: (2013)

Palladium-Catalyzed C–H Arylation of 1,2,3-Triazoles
por: Zhang, Chengwei, et al.
Publicado: (2016)

Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker
por: Głowacka, Iwona E., et al.
Publicado: (2015)

1,2,3-Triazole β-lactam conjugates as antimicrobial agents
por: Kaur, Rajneesh, et al.
Publicado: (2020)

Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates
por: Oramas-Royo, Sandra, et al.
Publicado: (2019)

Regioselective Reduction of 1H-1,2,3-Triazole Diesters
por: Butler, Christopher R., et al.
Publicado: (2021)

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity
por: Maghraby, Mohamed T-E, et al.
Publicado: (2023)

Pharmacokinetics of drospirenone and ethinylestradiol in Caucasian and Japanese women
por: Blode, Hartmut, et al.
Publicado: (2012)

Inhibitory effect of ethinylestradiol on coagulation factors in rats
por: Franco-Murillo, Yanira, et al.
Publicado: (2016)

Ethinylestradiol/Chlormadinone Acetate for Use in Dermatological Disorders
por: Vázquez, Mercedes Gómez, et al.
Publicado: (2012)

Synthesis of (1,2,3-triazol-4-yl)methyl Phosphinates and (1,2,3-Triazol-4-yl)methyl Phosphates by Copper-Catalyzed Azide-Alkyne Cycloaddition
por: Tripolszky, Anna, et al.
Publicado: (2019)

General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles
por: Gribanov, Pavel S., et al.
Publicado: (2022)

Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry
por: Buchanan, Devan, et al.
Publicado: (2023)

The role of charge in 1,2,3-triazol(ium)-based halogen bonding activators
por: Dreger, Alexander, et al.
Publicado: (2018)

Detecting Traces of 17α-Ethinylestradiol in Complex Water Matrices
por: Zagalo, Paulo M, et al.
Publicado: (2020)

Synthesis of 1,2,3-Triazole-Containing Methoxylated Cinnamides and Their Antileishmanial Activity against the Leishmania braziliensis Species
por: dos Santos, Fabíola Suelen, et al.
Publicado: (2023)

Synthesis and In Vitro Cytotoxicity and Antibacterial Activity of Novel 1,2,3-Triazol-5-yl-Phosphonates
por: Tripolszky, Anna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_la40huo1nj4utr34131bjj97g7