A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function

BACKGROUND: Tumors can employ different mechanisms to evade immune surveillance and function. Overexpression of co-inhibitory ligands that bind to checkpoint molecules on the surface of T-cells can greatly impair the function of latter. TIGIT (T cell immunoreceptor with Ig and ITIM domains) is such...

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Detalles Bibliográficos
Autores principales: Hoogi, Shiran, Eisenberg, Vasyl, Mayer, Shimrit, Shamul, Astar, Barliya, Tilda, Cohen, Cyrille J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734436/
https://www.ncbi.nlm.nih.gov/pubmed/31500665
http://dx.doi.org/10.1186/s40425-019-0721-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734436/
https://www.ncbi.nlm.nih.gov/pubmed/31500665
http://dx.doi.org/10.1186/s40425-019-0721-y

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