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A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function
BACKGROUND: Tumors can employ different mechanisms to evade immune surveillance and function. Overexpression of co-inhibitory ligands that bind to checkpoint molecules on the surface of T-cells can greatly impair the function of latter. TIGIT (T cell immunoreceptor with Ig and ITIM domains) is such...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734436/ https://www.ncbi.nlm.nih.gov/pubmed/31500665 http://dx.doi.org/10.1186/s40425-019-0721-y |