Synergistic Effect of a Mesothelin-Targeted (227)Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models

Targeted (227)Th conjugates (TTCs) represent a new class of therapeutic radiopharmaceuticals for targeted α-therapy. They comprise the α-emitter (227)Th complexed to a 3,2-hydroxypyridinone chelator conjugated to a tumor-targeting monoclonal antibody. The high energy and short range of the α-particl...

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Detalles Bibliográficos
Autores principales: Wickstroem, Katrine, Hagemann, Urs B., Cruciani, Véronique, Wengner, Antje M., Kristian, Alexander, Ellingsen, Christine, Siemeister, Gerhard, Bjerke, Roger M., Karlsson, Jenny, Ryan, Olav B., Linden, Lars, Mumberg, Dominik, Ziegelbauer, Karl, Cuthbertson, Alan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Nuclear Medicine 2019
Materias:
Theranostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735281/
https://www.ncbi.nlm.nih.gov/pubmed/30850485
http://dx.doi.org/10.2967/jnumed.118.223701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735281/
https://www.ncbi.nlm.nih.gov/pubmed/30850485
http://dx.doi.org/10.2967/jnumed.118.223701

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