Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model

The blood-brain barrier (BBB) restricts delivery of most chemotherapy agents to brain tumors. Here, we investigated a clinical focused ultrasound (FUS) device to disrupt the BBB in rats and enhance carboplatin delivery to the brain using the F98 glioma model. Methods: In each rat, 2-3 volumetric son...

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Detalles Bibliográficos
Autores principales: McDannold, Nathan, Zhang, Yongzhi, Supko, Jeffrey G., Power, Chanikarn, Sun, Tao, Peng, Chengueng, Vykhodtseva, Natalia, Golby, Alexandra J, Reardon, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735504/
https://www.ncbi.nlm.nih.gov/pubmed/31534551
http://dx.doi.org/10.7150/thno.35892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735504/
https://www.ncbi.nlm.nih.gov/pubmed/31534551
http://dx.doi.org/10.7150/thno.35892

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