ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma

Rationale: Activating transcription factor 4 (ATF4) is a central regulator of the cellular stress response and reduces tumor burden by controlling the expression of target genes implicated in the induction of apoptosis. Evidence shows ATF4 activation is responsible for proteasome inhibitor bortezomi...

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Detalles Bibliográficos
Autores principales: Luo, Jie, Xia, Yuanzheng, Yin, Yong, Luo, Jun, Liu, Mingming, Zhang, Hao, Zhang, Chao, Zhao, Yucheng, Yang, Lei, Kong, Lingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735522/
https://www.ncbi.nlm.nih.gov/pubmed/31534554
http://dx.doi.org/10.7150/thno.36818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735522/
https://www.ncbi.nlm.nih.gov/pubmed/31534554
http://dx.doi.org/10.7150/thno.36818

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