Role of Hepatic Glucocorticoid Receptor in Metabolism in Models of 5αR1 Deficiency in Male Mice

Inhibition of 5α-reductases impairs androgen and glucocorticoid metabolism and induces insulin resistance in humans and rodents. The contribution of hepatic glucocorticoids to these adverse metabolic changes was assessed using a liver-selective glucocorticoid receptor (GR) antagonist, A-348441. Mice...

Descripción completa

Detalles Bibliográficos
Autores principales: Mak, Tracy C S, Livingstone, Dawn E W, Nixon, Mark, Walker, Brian R, Andrew, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735737/
https://www.ncbi.nlm.nih.gov/pubmed/31199473
http://dx.doi.org/10.1210/en.2019-00236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735737/
https://www.ncbi.nlm.nih.gov/pubmed/31199473
http://dx.doi.org/10.1210/en.2019-00236

Ejemplares similares