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Differences in mutational processes and intra-tumour heterogeneity between organs: The local selective filter hypothesis
Extensive diversity (genetic, cytogenetic, epigenetic and phenotypic) exists within and between tumours, but reasons behind these variations, as well as their consistent hierarchical pattern between organs, are poorly understood at the moment. We argue that these phenomena are, at least partially, e...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735757/ https://www.ncbi.nlm.nih.gov/pubmed/31528343 http://dx.doi.org/10.1093/emph/eoz017 |