Large-scale analysis of human gene expression variability associates highly variable drug targets with lower drug effectiveness and safety

MOTIVATION: The effectiveness of drugs tends to vary between patients. One of the well-known reasons for this phenomenon is genetic polymorphisms in drug target genes among patients. Here, we propose that differences in expression levels of drug target genes across individuals can also contribute to...

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Detalles Bibliográficos
Autores principales: Simonovsky, Eyal, Schuster, Ronen, Yeger-Lotem, Esti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735839/
https://www.ncbi.nlm.nih.gov/pubmed/30649201
http://dx.doi.org/10.1093/bioinformatics/btz023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735839/
https://www.ncbi.nlm.nih.gov/pubmed/30649201
http://dx.doi.org/10.1093/bioinformatics/btz023

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