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Large-scale analysis of human gene expression variability associates highly variable drug targets with lower drug effectiveness and safety
MOTIVATION: The effectiveness of drugs tends to vary between patients. One of the well-known reasons for this phenomenon is genetic polymorphisms in drug target genes among patients. Here, we propose that differences in expression levels of drug target genes across individuals can also contribute to...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735839/ https://www.ncbi.nlm.nih.gov/pubmed/30649201 http://dx.doi.org/10.1093/bioinformatics/btz023 |