A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents

Type II topoisomerases catalyze essential DNA transactions and are proven drug targets. Drug discrimination by prokaryotic and eukaryotic topoisomerases is vital to therapeutic utility, but is poorly understood. We developed a next-generation sequencing (NGS) approach to identify drug-resistance mut...

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Detalles Bibliográficos
Autores principales: Blower, Tim R, Bandak, Afif, Lee, Amy S Y, Austin, Caroline A, Nitiss, John L, Berger, James M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735899/
https://www.ncbi.nlm.nih.gov/pubmed/31287876
http://dx.doi.org/10.1093/nar/gkz579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735899/
https://www.ncbi.nlm.nih.gov/pubmed/31287876
http://dx.doi.org/10.1093/nar/gkz579

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