Insights into the G-rich VEGF-binding aptamer V7t1: when two G-quadruplexes are better than one!

The G-quadruplex-forming VEGF-binding aptamer V7t1 was previously found to be highly polymorphic in a K(+)-containing solution and, to restrict its conformational preferences to a unique, well-defined form, modified nucleotides (LNA and/or UNA) were inserted in its sequence. We here report an in-dep...

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Detalles Bibliográficos
Autores principales: Moccia, Federica, Riccardi, Claudia, Musumeci, Domenica, Leone, Serena, Oliva, Rosario, Petraccone, Luigi, Montesarchio, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735921/
https://www.ncbi.nlm.nih.gov/pubmed/31276595
http://dx.doi.org/10.1093/nar/gkz589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735921/
https://www.ncbi.nlm.nih.gov/pubmed/31276595
http://dx.doi.org/10.1093/nar/gkz589

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