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From general base to general acid catalysis in a sodium-specific DNAzyme by a guanine-to-adenine mutation
Recently, a few Na(+)-specific RNA-cleaving DNAzymes were reported, where nucleobases are likely to play critical roles in catalysis. The NaA43 and NaH1 DNAzymes share the same 16-nt Na(+)-binding motif, but differ in one or two nucleotides in a small catalytic loop. Nevertheless, they display an op...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736077/ https://www.ncbi.nlm.nih.gov/pubmed/31276580 http://dx.doi.org/10.1093/nar/gkz578 |