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Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy
EGFR mutations display striking organ-site asymmetry and heterogeneity. We have shown that structurally diverse extracellular mutations, typical of glioblastomas, converge to a similar intermediate conformation, which can be synergistically targeted extra- and intracelullarly by antibody mAb806 and...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736128/ https://www.ncbi.nlm.nih.gov/pubmed/31528699 http://dx.doi.org/10.1080/23723556.2019.1630798 |