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Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736317/ https://www.ncbi.nlm.nih.gov/pubmed/31528687 http://dx.doi.org/10.1080/23723556.2018.1536843 |