Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells

Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleo...

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Autores principales: Alkan, H. Furkan, Bogner-Strauss, Juliane G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736317/
https://www.ncbi.nlm.nih.gov/pubmed/31528687
http://dx.doi.org/10.1080/23723556.2018.1536843
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author Alkan, H. Furkan
Bogner-Strauss, Juliane G.
author_facet Alkan, H. Furkan
Bogner-Strauss, Juliane G.
author_sort Alkan, H. Furkan
collection PubMed
description Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis.
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spelling pubmed-67363172020-07-09 Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells Alkan, H. Furkan Bogner-Strauss, Juliane G. Mol Cell Oncol Author’s Views Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis. Taylor & Francis 2019-07-09 /pmc/articles/PMC6736317/ /pubmed/31528687 http://dx.doi.org/10.1080/23723556.2018.1536843 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Alkan, H. Furkan
Bogner-Strauss, Juliane G.
Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
title Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
title_full Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
title_fullStr Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
title_full_unstemmed Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
title_short Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
title_sort maintaining cytosolic aspartate levels is a major function of the tca cycle in proliferating cells
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736317/
https://www.ncbi.nlm.nih.gov/pubmed/31528687
http://dx.doi.org/10.1080/23723556.2018.1536843
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