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Shared Signature Dynamics Tempered by Local Fluctuations Enables Fold Adaptability and Specificity

Recent studies have drawn attention to the evolution of protein dynamics, in addition to sequence and structure, based on the premise structure-encodes-dynamics-encodes-function. Of interest is to understand how functional differentiation is accomplished while maintaining the fold, or how intrinsic...

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Detalles Bibliográficos
Autores principales: Zhang, She, Li, Hongchun, Krieger, James M, Bahar, Ivet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736388/
https://www.ncbi.nlm.nih.gov/pubmed/31028708
http://dx.doi.org/10.1093/molbev/msz102