RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination. Specialized nucleases, termed resolvases, remove (i.e., resolve) HJs. The bacterial protein RuvC is a canonical resolvase that introduces two symmetric cuts into the HJ. For complete resolution...

Descripción completa

Detalles Bibliográficos
Autores principales: Górecka, Karolina Maria, Krepl, Miroslav, Szlachcic, Aleksandra, Poznański, Jarosław, Šponer, Jiří, Nowotny, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736871/
https://www.ncbi.nlm.nih.gov/pubmed/31506434
http://dx.doi.org/10.1038/s41467-019-11900-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736871/
https://www.ncbi.nlm.nih.gov/pubmed/31506434
http://dx.doi.org/10.1038/s41467-019-11900-8

Ejemplares similares