Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the lifetime of C3bBb-enzyme complexes that convert C3 i...

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Detalles Bibliográficos
Autores principales: van den Bos, Ramon M., Pearce, Nicholas M., Granneman, Joke, Brondijk, T. Harma C., Gros, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736995/
https://www.ncbi.nlm.nih.gov/pubmed/31552043
http://dx.doi.org/10.3389/fimmu.2019.02097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736995/
https://www.ncbi.nlm.nih.gov/pubmed/31552043
http://dx.doi.org/10.3389/fimmu.2019.02097

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