Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing neurodegeneration. Here, we show that HEK293...

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Detalles Bibliográficos
Autores principales: Morozova, Viktoriya, Cohen, Leah S., Makki, Ali El-Hadi, Shur, Alison, Pilar, Guillermo, El Idrissi, Abdeslem, Alonso, Alejandra D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737038/
https://www.ncbi.nlm.nih.gov/pubmed/31555098
http://dx.doi.org/10.3389/fncel.2019.00403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737038/
https://www.ncbi.nlm.nih.gov/pubmed/31555098
http://dx.doi.org/10.3389/fncel.2019.00403

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