Cargando…

MARK4 protein can explore the active-like conformations in its non-phosphorylated state

Microtubule affinity-regulating kinase 4 (MARK4) is a Ser/Thr protein kinase, best known for its role in phosphorylating microtubule associated proteins, causing their detachment from microtubules. In the current study, the non-phosphorylated conformation of the activation loop was modeled in a stru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahrari, Sajjad, Khosravi, Fatemeh, Osouli, Ali, Sakhteman, Amirhossein, Nematollahi, Alireza, Ghasemi, Younes, Savardashtaki, Amir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737064/ https://www.ncbi.nlm.nih.gov/pubmed/31506531 http://dx.doi.org/10.1038/s41598-019-49337-0

Ejemplares similares

Effects of T208E activating mutation on MARK2 protein structure and dynamics: Modeling and simulation
por: Ahrari, Sajjad, et al.
Publicado: (2014)

Adipose Tissue Derived Multipotent Mesenchymal Stromal Cells Can Be Isolated Using Serum-free Media
por: Ahrari, Iman, et al.
Publicado: (2013)

B-Cell Epitope Mapping from Eight Antigens of Candida albicans to Design a Novel Diagnostic Kit: An Immunoinformatics Approach
por: Vahedi, Farzaneh, et al.
Publicado: (2022)

In silico analysis of suitable signal peptides for secretion of a recombinant alcohol dehydrogenase with a key role in atorvastatin enzymatic synthesis
por: Taheri-Anganeh, Mortaza, et al.
Publicado: (2019)

Designing a Multi-Epitope Antigen for Serodiagnosis of Strongyloides stercoralis Based on L3Nie.01 and IgG Immunoreactive Epitopes
por: Movahedpour, Ahmad, et al.
Publicado: (2022)

Modelface: an Application Programming Interface (API) for Homology Modeling Studies Using Modeller Software
por: Sakhteman, Amirhossein, et al.
Publicado: (2016)

Partial least Squares- least squares- Support Vector Machine Modeling of ATR-IR as a Spectrophotometric Method for Detection and Determination of Iron in Pharmaceutical Formulations
por: Parhizkar, Elahehnaz, et al.
Publicado: (2019)

In silico Evaluation of PLAC1-fliC As a Chimeric Vaccine against Breast Cancer
por: Taheri-Anganeh, Mortaza, et al.
Publicado: (2020)

LytU-SH3b fusion protein as a novel and efficient enzybiotic against methicillin-resistant Staphylococcus aureus
por: Taheri-Anganeh, Mortaza, et al.
Publicado: (2019)

In Silico Design and Evaluation of PRAME+FliCΔD2D3 as a New Breast Cancer Vaccine Candidate
por: Taheri-Anganeh, Mortaza, et al.
Publicado: (2021)

De novo design of novel protease inhibitor candidates in the treatment of SARS-CoV-2 using deep learning, docking, and molecular dynamic simulations
por: Arshia, Amir Hossein, et al.
Publicado: (2021)

Laboratory Findings of COVID-19 Infection are Conflicting in Different Age Groups and Pregnant Women: A Literature Review
por: Vakili, Sina, et al.
Publicado: (2020)

LYZ2-SH3b as a novel and efficient enzybiotic against methicillin-resistant Staphylococcus aureus
por: Asadi, Marzieh, et al.
Publicado: (2023)

EDTox: an R Shiny application to predict the endocrine disruption potential of compounds
por: Sakhteman, Amirhossein, et al.
Publicado: (2022)

Anti-Toxoplasma gondii activity of 5-oxo-hexahydroquinoline derivatives: synthesis, in vitro and in vivo evaluations, and molecular docking analysis
por: Zahedi, Mohammadsaeid, et al.
Publicado: (2020)

Circular RNAs in cancer: new insights into functions and implications in ovarian cancer
por: Shabaninejad, Zahra, et al.
Publicado: (2019)

Non-adaptive Evolution of Trimeric Autotransporters in Brucellaceae
por: Rahbar, Mohammad Reza, et al.
Publicado: (2020)

TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus
por: Yousefi, Fatemeh, et al.
Publicado: (2020)

Potential inhibitors of the main protease of SARS-CoV-2 and modulators of arachidonic acid pathway: Non-steroidal anti-inflammatory drugs against COVID-19
por: Sisakht, Mohsen, et al.
Publicado: (2021)

Comparison of Intradermal Injection of Autologous Epidermal Cell Suspension vs. Spraying of these Cells on Dermabraded Surface of Skin of Patients with Post-Burn Hypopigmentation
por: Iman, Ahrari, et al.
Publicado: (2013)

A quantitative structure-activity relationship (QSAR) study of some diaryl urea derivatives of B-RAF inhibitors
por: Sadeghian-Rizi, Sedighe, et al.
Publicado: (2016)

In Silico Screening of IL-1β Production Inhibitors Using Chemometric Tools
por: Sakhteman, Amirhossein, et al.
Publicado: (2017)

An Assay on the Possible Effect of Essential Oil Constituents on Receptors Involved in Women’s Hormonal Health and Reproductive System Diseases
por: Sakhteman, Amirhossein, et al.
Publicado: (2020)

Marked Difference in the Conformational Transition of DNA Caused by Propanol Isomer
por: Ma, Yue, et al.
Publicado: (2020)

MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer’s disease granulovacuolar degeneration bodies
por: Lund, Harald, et al.
Publicado: (2014)

In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau
por: Zhang, Shengnan, et al.
Publicado: (2018)

A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
por: Mosaddeghi, Pouria, et al.
Publicado: (2021)

Author Correction: A systems pharmacology approach to identify the autophagy‑inducing effects of Traditional Persian medicinal plants
por: Mosaddeghi, Pouria, et al.
Publicado: (2021)

A Comparative QSAR Analysis, Molecular Docking and PLIF Studies of Some N-arylphenyl-2, 2-Dichloroacetamide Analogues as Anticancer Agents
por: Fereidoonnezhad, Masood, et al.
Publicado: (2017)

Can COVID-19 present unusual GI symptoms?
por: Hormati, Ahmad, et al.
Publicado: (2020)

Phytochemical Analysis and Biological Activity of Salvia compressa Vent.
por: Noorbakhsh, Firoozeh, et al.
Publicado: (2022)

MARK2 phosphorylates eIF2α in response to proteotoxic stress
por: Lu, Yu-Ning, et al.
Publicado: (2021)

Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
por: Vafadar, Asma, et al.
Publicado: (2020)

An Overview on Indications and Chemical Composition of Aromatic Waters (Hydrosols) as Functional Beverages in Persian Nutrition Culture and Folk Medicine for Hyperlipidemia and Cardiovascular Conditions
por: Hamedi, Azadeh, et al.
Publicado: (2017)

5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety
por: Nadri, Hamid, et al.
Publicado: (2013)

Phosphorylation Induced Conformational Transitions in DNA Polymerase β
por: Srivastava, Amit, et al.
Publicado: (2022)

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
por: Timm, Thomas, et al.
Publicado: (2008)

Integrating Rigidity Analysis into the Exploration of Protein Conformational Pathways Using RRT* and MC
por: Afrasiabi, Fatemeh, et al.
Publicado: (2021)

Exploring the conformational diversity of proteins
por: Schlessinger, Avner, et al.
Publicado: (2022)

The Active Site of a Prototypical “Rigid” Drug Target is Marked by Extensive Conformational Dynamics
por: Singh, Himanshu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j2drlsjce8kcvnj61o2n2pvqmu