Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor α Transcriptional Activity in Breast Cancer Cell Lines

The most frequently diagnosed cancers in women are the estrogen receptor (ER)-positive breast cancer subtypes, which are characterized by estrogen dependency for their growth. The mainstay of clinical treatment for this tumor relies on the modulation of ERα action or on the suppression of estrogen b...

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Detalles Bibliográficos
Autores principales: Pavlin, Matic, Gelsomino, Luca, Barone, Ines, Spinello, Angelo, Catalano, Stefania, Andò, Sebastiano, Magistrato, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737084/
https://www.ncbi.nlm.nih.gov/pubmed/31552220
http://dx.doi.org/10.3389/fchem.2019.00602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737084/
https://www.ncbi.nlm.nih.gov/pubmed/31552220
http://dx.doi.org/10.3389/fchem.2019.00602

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