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Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

L-lactate was long considered a glycolytic by-product but is now being recognized as a signaling molecule involved in cell survival. In this manuscript, we report the role of L-lactate in stress resistance and cell survival mechanisms using neuroblastoma cells (SH-SY5Y) as well as the C. elegans mod...

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Detalles Bibliográficos
Autores principales: Tauffenberger, Arnaud, Fiumelli, Hubert, Almustafa, Salam, Magistretti, Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737085/
https://www.ncbi.nlm.nih.gov/pubmed/31506428
http://dx.doi.org/10.1038/s41419-019-1877-6