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Heteroplasmy concordance between mitochondrial DNA and RNA

Mitochondrial DNA (mtDNA) heteroplasmies are associated with various diseases but the transmission of heteroplasmy from mtDNA to mitochondrial RNA (mtRNA) remains unclear. We compared heteroplasmies in mtRNA from 446 human B-lymphoblastoid cell lines to their corresponding mtDNA using deep sequencin...

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Detalles Bibliográficos
Autores principales: Zhang, Ruoyu, Nakahira, Kiichi, Choi, Augustine M. K., Gu, Zhenglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737107/
https://www.ncbi.nlm.nih.gov/pubmed/31506522
http://dx.doi.org/10.1038/s41598-019-49279-7