A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labels

Bax is a Bcl-2 protein crucial for apoptosis initiation and execution, whose active conformation is only partially understood. Dipolar EPR spectroscopy has proven to be a valuable tool to determine coarse-grained models of membrane-embedded Bcl-2 proteins. Here we show how the combination of spectro...

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Detalles Bibliográficos
Autores principales: Teucher, Markus, Zhang, Hui, Bader, Verian, Winklhofer, Konstanze F., García-Sáez, Ana J., Rajca, Andrzej, Bleicken, Stephanie, Bordignon, Enrica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737250/
https://www.ncbi.nlm.nih.gov/pubmed/31506457
http://dx.doi.org/10.1038/s41598-019-49370-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737250/
https://www.ncbi.nlm.nih.gov/pubmed/31506457
http://dx.doi.org/10.1038/s41598-019-49370-z

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