Three-Dimensional Heart Model-Based Screening of Proarrhythmic Potential by in silico Simulation of Action Potential and Electrocardiograms

The proarrhythmic risk is a major concern in drug development. The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative has proposed the JTpeak interval on electrocardiograms (ECGs) and qNet, an in silico metric, as new biomarkers that may overcome the limitations of the hERG assay and QT in...

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Detalles Bibliográficos
Autores principales: Hwang, Minki, Han, Seunghoon, Park, Min Cheol, Leem, Chae Hun, Shim, Eun Bo, Yim, Dong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738014/
https://www.ncbi.nlm.nih.gov/pubmed/31551815
http://dx.doi.org/10.3389/fphys.2019.01139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738014/
https://www.ncbi.nlm.nih.gov/pubmed/31551815
http://dx.doi.org/10.3389/fphys.2019.01139

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