EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltransferase that deposits the repressive H3K27me3 histone mark, it can cooper...

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Detalles Bibliográficos
Autores principales: Tabbal, Houda, Septier, Amandine, Mathieu, Mickael, Drelon, Coralie, Rodriguez, Stéphanie, Djari, Cyril, Batisse-Lignier, Marie, Tauveron, Igor, Pointud, Jean-Christophe, Sahut-Barnola, Isabelle, Ragazzon, Bruno, Assié, Guillaume, Bertherat, Jérôme, Lefrançois-Martinez, Anne-Marie, Martinez, Antoine, Val, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738105/
https://www.ncbi.nlm.nih.gov/pubmed/31363169
http://dx.doi.org/10.1038/s41416-019-0538-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738105/
https://www.ncbi.nlm.nih.gov/pubmed/31363169
http://dx.doi.org/10.1038/s41416-019-0538-y

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