Standardization of Sequencing Coverage Depth in NGS: Recommendation for Detection of Clonal and Subclonal Mutations in Cancer Diagnostics

The insufficient standardization of diagnostic next-generation sequencing (NGS) still limits its implementation in clinical practice, with the correct detection of mutations at low variant allele frequencies (VAF) facing particular challenges. We address here the standardization of sequencing covera...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrackova, Anna, Vasinek, Michal, Sedlarikova, Lenka, Dyskova, Tereza, Schneiderova, Petra, Novosad, Tomas, Papajik, Tomas, Kriegova, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738196/
https://www.ncbi.nlm.nih.gov/pubmed/31552176
http://dx.doi.org/10.3389/fonc.2019.00851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738196/
https://www.ncbi.nlm.nih.gov/pubmed/31552176
http://dx.doi.org/10.3389/fonc.2019.00851

Ejemplares similares