Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes

The germinal center (GC) is the anatomical site where humoral immunity evolves. B cells undergo cycles of proliferation and selection to produce high-affinity Abs against Ag. Direct linkage of a TLR9 agonist (CpG) to a T-dependent Ag increases the number of GC B cells. We used a T-dependent Ag compl...

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Detalles Bibliográficos
Autores principales: Wigton, Eric J., DeFranco, Anthony L., Ansel, K. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738343/
https://www.ncbi.nlm.nih.gov/pubmed/31427364
http://dx.doi.org/10.4049/immunohorizons.1900030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738343/
https://www.ncbi.nlm.nih.gov/pubmed/31427364
http://dx.doi.org/10.4049/immunohorizons.1900030

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