Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age

BACKGROUND AND OBJECTIVES: Samidorphan (SAM) is a novel μ-opioid receptor antagonist. We report clinical pharmacokinetic (PK) properties of SAM following different routes of administration, and the effects of food and age on the PK of SAM following oral administration in healthy volunteers. METHODS:...

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Detalles Bibliográficos
Autores principales: Kumar, Vipul, Lu, Hong, Hard, Marjie, von Moltke, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738372/
https://www.ncbi.nlm.nih.gov/pubmed/31463821
http://dx.doi.org/10.1007/s40268-019-00280-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738372/
https://www.ncbi.nlm.nih.gov/pubmed/31463821
http://dx.doi.org/10.1007/s40268-019-00280-5

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