Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be counteracted. Intracellular calcium (Ca(2+)(i)) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are critical factors that contribute to senescen...

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Detalles Bibliográficos
Autores principales: Granzotto, Alberto, Bomba, Manuela, Castelli, Vanessa, Navarra, Riccardo, Massetti, Noemi, d’Aurora, Marco, Onofrj, Marco, Cicalini, Ilaria, del Boccio, Piero, Gatta, Valentina, Cimini, Annamaria, Piomelli, Daniele, Sensi, Stefano L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738398/
https://www.ncbi.nlm.nih.gov/pubmed/31467258
http://dx.doi.org/10.18632/aging.102191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738398/
https://www.ncbi.nlm.nih.gov/pubmed/31467258
http://dx.doi.org/10.18632/aging.102191

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