Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity

Alzheimer’s disease (AD) is accompanied by the dysfunction of intracellular protein homeostasis systems, in particular the ubiquitin-proteasome system (UPS). Beta-amyloid peptide (Aβ), which is involved in the processes of neurodegeneration in AD, is a substrate of this system, however its effect on...

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Detalles Bibliográficos
Autores principales: Kechko, Olga I., Petrushanko, Irina Yu., Brower, Christopher S., Adzhubei, Alexei A., Moskalev, Alexey A., Piatkov, Konstantin I., Mitkevich, Vladimir A., Makarov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738421/
https://www.ncbi.nlm.nih.gov/pubmed/31446431
http://dx.doi.org/10.18632/aging.102177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738421/
https://www.ncbi.nlm.nih.gov/pubmed/31446431
http://dx.doi.org/10.18632/aging.102177

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