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Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity

Alzheimer’s disease (AD) is accompanied by the dysfunction of intracellular protein homeostasis systems, in particular the ubiquitin-proteasome system (UPS). Beta-amyloid peptide (Aβ), which is involved in the processes of neurodegeneration in AD, is a substrate of this system, however its effect on...

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Detalles Bibliográficos
Autores principales:	Kechko, Olga I., Petrushanko, Irina Yu., Brower, Christopher S., Adzhubei, Alexei A., Moskalev, Alexey A., Piatkov, Konstantin I., Mitkevich, Vladimir A., Makarov, Alexander A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738421/ https://www.ncbi.nlm.nih.gov/pubmed/31446431 http://dx.doi.org/10.18632/aging.102177

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