Reshuffling yeast chromosomes with CRISPR/Cas9

Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confounding effect of base substitutions has so far remained challenging. We report a novel application of the CRISPR/C...

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Detalles Bibliográficos
Autores principales: Fleiss, Aubin, O'Donnell, Samuel, Fournier, Téo, Lu, Wenqing, Agier, Nicolas, Delmas, Stéphane, Schacherer, Joseph, Fischer, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738639/
https://www.ncbi.nlm.nih.gov/pubmed/31465441
http://dx.doi.org/10.1371/journal.pgen.1008332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738639/
https://www.ncbi.nlm.nih.gov/pubmed/31465441
http://dx.doi.org/10.1371/journal.pgen.1008332

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