Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers

Cancers often overexpress anti-apoptotic Bcl-2 proteins for cell death evasion, a recognized hallmark of cancer progression. While estrogen receptor (ER)-α+ breast cancers express high levels of three anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1), pharmacological inhibition of Bcl-2...

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Detalles Bibliográficos
Autores principales: Williams, Michelle M., Elion, David L., Rahman, Bushra, Hicks, Donna J., Sanchez, Violeta, Cook, Rebecca S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739218/
https://www.ncbi.nlm.nih.gov/pubmed/31595181
http://dx.doi.org/10.18632/oncotarget.27070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739218/
https://www.ncbi.nlm.nih.gov/pubmed/31595181
http://dx.doi.org/10.18632/oncotarget.27070

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