Cargando…

TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of the STimulator of INterferon Genes (STING) by DMXAA (5,6-dimethylxanthenone-4-acetic acid) can induce strong production of IFNα/β and rejection of transplanted primary tumors. In the present study, we addres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guerin, Marion V., Regnier, Fabienne, Feuillet, Vincent, Vimeux, Lene, Weiss, Julia M., Bismuth, Georges, Altan-Bonnet, Gregoire, Guilbert, Thomas, Thoreau, Maxime, Finisguerra, Veronica, Donnadieu, Emmanuel, Trautmann, Alain, Bercovici, Nadège
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739328/ https://www.ncbi.nlm.nih.gov/pubmed/31511510 http://dx.doi.org/10.1038/s41467-019-11998-w

Ejemplares similares

Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse
por: Guerin, Marion v, et al.
Publicado: (2020)

The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression
por: Weiss, Julia M., et al.
Publicado: (2017)

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment
por: Peranzoni, Elisa, et al.
Publicado: (2018)

Preclinical murine tumor models: A structural and functional perspective
por: Guerin, Marion V, et al.
Publicado: (2020)

The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer
por: Bercovici, Nadège, et al.
Publicado: (2019)

Revisiting the role of T cells in tumor regression
por: Bercovici, Nadège, et al.
Publicado: (2012)

Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site
por: Thoreau, Maxime, et al.
Publicado: (2015)

Vaccine-induced tumor regression requires a multi-step cooperation between T cells and myeloid cells at the tumor site
por: Thoreau, Maxime, et al.
Publicado: (2015)

Exploring the immunomodulatory role of virtual memory CD8(+) T cells: Role of IFN gamma in tumor growth control
por: Savid-Frontera, Constanza, et al.
Publicado: (2022)

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment
por: Nicolas-Boluda, Alba, et al.
Publicado: (2021)

CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3–kinase– independent manner
por: Asperti-Boursin, François, et al.
Publicado: (2007)

Bispecific Antibodies for IFN-β Delivery to ErbB2(+) Tumors
por: Rybchenko, Vladislav S., et al.
Publicado: (2021)

Antigen-dependent and -independent Ca(2+) Responses Triggered in T Cells by Dendritic Cells Compared with B Cells
por: Delon, Jérôme, et al.
Publicado: (1998)

Early T Cell Signalling Is Reversibly Altered in PD-1(+) T Lymphocytes Infiltrating Human Tumors
por: Wang, Shu-Fang, et al.
Publicado: (2011)

The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway
por: Takahashi, Mariko, et al.
Publicado: (2021)

Dynamic CD8(+) T Cell Cooperation with Macrophages and Monocytes for Successful Cancer Immunotherapy
por: Vermare, Anaïs, et al.
Publicado: (2022)

The Different Effects of IFN-β and IFN-γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells
por: Du, Jingchun, et al.
Publicado: (2019)

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection
por: Steele, Lynette, et al.
Publicado: (2021)

Release of Interferon-β (IFN-β) from Probiotic Limosilactobacillus reuteri-IFN-β (LR-IFN-β) Mitigates Gastrointestinal Acute Radiation Syndrome (GI-ARS) following Whole Abdominal Irradiation
por: Hamade, Diala F., et al.
Publicado: (2023)

IFN-β for the treatment of rheumatoid arthritis?
por: Tak, P, et al.
Publicado: (2003)

Tumor Rejection by Modulation of Tumor Stromal Fibroblasts
por: Schüler, Thomas, et al.
Publicado: (2003)

Influence of stromal elements on resident T cell migration in human and murine tumors analyzed by real-time imaging
por: Peranzoni, Elisa, et al.
Publicado: (2015)

IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors
por: Alshaker, Heba A, et al.
Publicado: (2011)

Nurselike cells sequester B cells in disorganized lymph nodes in chronic lymphocytic leukemia via alternative production of CCL21
por: Zaaboub, Rim, et al.
Publicado: (2022)

Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease
por: Fox, Lindsey E., et al.
Publicado: (2020)

Dendritic Cells Crosspresent Antigens from Live B16 Cells More Efficiently than from Apoptotic Cells and Protect from Melanoma in a Therapeutic Model
por: Matheoud, Diana, et al.
Publicado: (2011)

Tumor Rejection by Disturbing Tumor Stroma Cell Interactions
por: Ibe, Sabrina, et al.
Publicado: (2001)

The Comparison Between the Mutated HuIFN-β 27-101 and the Wild Type Interferon β: the Comprehensive In Silico Study to Evaluate the Effect of Mutations on IFN-β
por: Balkhi, Sayed Sharif, et al.
Publicado: (2019)

IFN-γ Mediates the Rejection of Haematopoietic Stem Cells in IFN-γR1-Deficient Hosts
por: Rottman, Martin, et al.
Publicado: (2008)

Glycosylation Heterogeneity of Hyperglycosylated Recombinant Human Interferon-β (rhIFN-β)
por: Song, Kyoung, et al.
Publicado: (2020)

Differential regulation of IFNα, IFNβ and IFNε gene expression in human cervical epithelial cells
por: Couret, Jennifer, et al.
Publicado: (2017)

T Cells Contribute to Tumor Progression by Favoring Pro-Tumoral Properties of Intra-Tumoral Myeloid Cells in a Mouse Model for Spontaneous Melanoma
por: Lengagne, Renée, et al.
Publicado: (2011)

An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages
por: Sheikh, Faruk, et al.
Publicado: (2014)

Chicken DDX3X Activates IFN-β via the chSTING-chIRF7-IFN-β Signaling Axis
por: Niu, Qiaona, et al.
Publicado: (2019)

Within tumors, interactions between T cells and tumor cells are impeded by the extracellular matrix
por: Salmon, Hélène, et al.
Publicado: (2012)

Analysis of the IFN-γ-induced signal transduction pathway in fetal rejection
por: Athanassakis, Irene
Publicado: (1995)

Prevention of SHIV transmission by topical IFN-β treatment
por: Veazey, Ronald S., et al.
Publicado: (2016)

Deficient pulmonary IFN‐β expression in COPD patients
por: García-Valero, José, et al.
Publicado: (2019)

β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma
por: Bruno, Gennaro, et al.
Publicado: (2023)

Peritumoral administration of IFNβ upregulated mesenchymal stem cells inhibits tumor growth in an orthotopic, immunocompetent rat glioma model
por: Mao, Jiaji, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8ti9rp9anhvrn4vjbu97m3s4dh