Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- and TLR4. Here we identify USP19 as a negative regulator of TLR3/4-mediated signaling. USP19 deficiency increases the production of...

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Detalles Bibliográficos
Autores principales: Wu, Xin, Lei, Caoqi, Xia, Tian, Zhong, Xuan, Yang, Qing, Shu, Hong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739404/
https://www.ncbi.nlm.nih.gov/pubmed/31511519
http://dx.doi.org/10.1038/s41467-019-12145-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739404/
https://www.ncbi.nlm.nih.gov/pubmed/31511519
http://dx.doi.org/10.1038/s41467-019-12145-1

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